Small molecules which mimic Metformin treatment
Canned Analysis
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General Information
AccessionDCA00012948
TitleSmall molecules which mimic Metformin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Metformin treatment in the liver cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1da90e467bea600fb9144
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgswaminath
CREEDS IDdrug:3308
Cell Typeliver
Drug NameMetformin
DrugBank IDDB00331
Organismmouse
PubChem CID4091
SMILES IDCN(C)C(=N)N=C(N)N
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM878116, GSM878117, GSM878118, GSM878119, GSM878120, GSM878121, GSM878122, GSM878123
Perturbed SamplesGSM878124, GSM878125, GSM878126, GSM878127
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE35961
Gene Expression Omnibus
Liver response to a metformin supplemented high fat diet deficient in methionine and choline
7
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