Small molecules which mimic Trichloroethylene treatment
Canned Analysis
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General Information
AccessionDCA00012950
TitleSmall molecules which mimic Trichloroethylene treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Trichloroethylene treatment in the Liver (129S1/SvImJ strain) - 24 hours after treatment cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d1a1e467bea600fb8d50
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3309
Cell TypeLiver (129S1/SvImJ strain) - 24 hours after treatment
Drug NameTrichloroethylene
Organismmouse
PubChem CID6575
SMILES IDC(=C(Cl)Cl)Cl
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM597130, GSM597144, GSM597168
Perturbed SamplesGSM597077, GSM597095, GSM597113
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE24278
Gene Expression Omnibus
Interstrain differences in the liver effects of trichloroethylene
98
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