Small molecules which reverse Pyrazinamide treatment
Canned Analysis
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General Information
AccessionDCA00012979
TitleSmall molecules which reverse Pyrazinamide treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Pyrazinamide treatment in the Lung (from B6D2F1 females infected with Mycobacterium tuberculosis) - 42 days post infection cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ec1ce467bea600fb98fc
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3325
Cell TypeLung (from B6D2F1 females infected with Mycobacterium tuberculosis) - 42 days post infection
Drug NamePyrazinamide
DrugBank IDDB00339
Organismmouse
PubChem CID1046
SMILES IDC1=CN=C(C=N1)C(=O)N
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1165960, GSM1165961, GSM1165962, GSM1165963, GSM1165964, GSM1165965
Perturbed SamplesGSM1165968, GSM1165969
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE48027
Gene Expression Omnibus
Pyrazinamide effect on pulmonary tuberculosis model : time course
28
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