Small molecules which reverse Dexamethasone treatment
Canned Analysis
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General Information
AccessionDCA00012995
TitleSmall molecules which reverse Dexamethasone treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Dexamethasone treatment in the LUNGS of C57BL/6 males (AIN-76A on Diet) - Injection 1mg/kg cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1dcf3e467bea600fb9256
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3358
Cell TypeLUNGS of C57BL/6 males (AIN-76A on Diet) - Injection 1mg/kg
Drug NameDexamethasone
DrugBank IDDB01234
Organismmouse
PubChem CID5743
SMILES IDCC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM279232, GSM279235, GSM279264, GSM279270, GSM279275
Perturbed SamplesGSM279233, GSM279236, GSM279239, GSM279247, GSM279252
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11056
Gene Expression Omnibus
Lung response to chronic and acute exposure to ingested arsenic
56
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