Small molecules which reverse Insulin treatment
Canned Analysis
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General Information
AccessionDCA00013009
TitleSmall molecules which reverse Insulin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Insulin treatment in the Skeletal muscle - Vastus lateralis muscle biopsies - from insulin-sensitive subjects cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d5dee467bea600fb8f2e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3368
Cell TypeSkeletal muscle - Vastus lateralis muscle biopsies - from insulin-sensitive subjects
Drug NameInsulin
Organismhuman
PubChem CID3989
SMILES IDC1=CC=C2C(=C1)C(=CN2)CC(C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CCCCN)N
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM555237, GSM555239, GSM555241, GSM555243, GSM555245, GSM555247, GSM555249, GSM555251, GSM555253, GSM555255, GSM555257, GSM555259, GSM555261, GSM555263, GSM555265, GSM555267, GSM555269, GSM555271, GSM555273, GSM555275
Perturbed SamplesGSM555238, GSM555240, GSM555242, GSM555244, GSM555246, GSM555248, GSM555250, GSM555252, GSM555254, GSM555256, GSM555258, GSM555260, GSM555262, GSM555264, GSM555266, GSM555268, GSM555270, GSM555272, GSM555274, GSM555276
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE22309
Gene Expression Omnibus
Insulin effect on skeletal muscle
14
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