Small molecules which reverse Pbde 47 treatment
Canned Analysis
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General Information
AccessionDCA00013043
TitleSmall molecules which reverse Pbde 47 treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Pbde 47 treatment in the LIVERS (animals exposed to low doses from gestational day 15 to post-natal day 20) - 0.002mg/kg cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e0a8e467bea600fb93f6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3392
Cell TypeLIVERS (animals exposed to low doses from gestational day 15 to post-natal day 20) - 0.002mg/kg
Drug NamePbde 47
Organismrat
PubChem CID95170
SMILES IDC1=CC(=C(C=C1Br)Br)OC2=C(C=C(C=C2)Br)Br
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM496404, GSM496405, GSM496406, GSM496407, GSM496408, GSM496409
Perturbed SamplesGSM496410, GSM496411, GSM496412, GSM496413, GSM496414, GSM496415
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE19868
Gene Expression Omnibus
Liver response to perinatal exposure to 2,2',4,4'-tetrabromodiphenyl ether: dose response
14
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