Small molecules which reverse Estradiol treatment
Canned Analysis
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General Information
AccessionDCA00013047
TitleSmall molecules which reverse Estradiol treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Estradiol treatment in the Endothelial cells (cultured umbilical vein endothelial cells) - treated with 1 nmol/L estradiol for 24 hours cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e0bbe467bea600fb93fe
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3394
Cell TypeEndothelial cells (cultured umbilical vein endothelial cells) - treated with 1 nmol/L estradiol for 24 hours
Drug NameEstradiol
DrugBank IDDB00783
Organismhuman
PubChem CID5757
SMILES IDCC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM418126, GSM418127, GSM418128
Perturbed SamplesGSM418129, GSM418130, GSM418131
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE16683
Gene Expression Omnibus
Endothelial cell response to estradiol in vitro
7
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