Small molecules which reverse 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) treatment
Canned Analysis
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General Information
AccessionDCA00013085
TitleSmall molecules which reverse 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) treatment in the HL-60 cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e458e467bea600fb9596
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:3426
Cell TypeHL-60 cells
Drug Name2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)
Organismhuman
PubChem CID15625
SMILES IDC1=C2C(=CC(=C1Cl)Cl)OC3=CC(=C(C=C3O2)Cl)Cl
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM405501, GSM405502
Perturbed SamplesGSM405499, GSM405500
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE16160
Gene Expression Omnibus
Expression data of HL-60 leukemia cells after treatment with Curcumin and TCDD
14
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