Small molecules which reverse Calcitonin treatment
Canned Analysis
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General Information
AccessionDCA00013121
TitleSmall molecules which reverse Calcitonin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Calcitonin treatment in the osteoclasts (wild type) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ee63e467bea600fb9a00
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:3446
Cell Typeosteoclasts (wild type)
Drug NameCalcitonin
Organismmouse
PubChem CID16132288
SMILES IDCCC(C)C(C(=O)NCC(=O)NC(C(C)C)C(=O)NCC(=O)NC(C)C(=O)N1CCCC1C(=O)N)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(CCC(=O)N)NC(=O)C2CCCN2C(=O)C(CC3=CC=CC=C3)NC(=O)C(C(C)O)NC(=O)C(CC4=CN=CN4)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CC6=CC=CC=C6)NC(=O)C(CC(
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1487524, GSM1487525, GSM1487526
Perturbed SamplesGSM1487527, GSM1487528, GSM1487529
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE60761
Gene Expression Omnibus
Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts
21
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