Small molecules which reverse Ubiquinol treatment
Canned Analysis
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General Information
AccessionDCA00013125
TitleSmall molecules which reverse Ubiquinol treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Ubiquinol treatment in the monocyte cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ee90e467bea600fb9a14
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:3448
Cell Typemonocyte
Drug NameUbiquinol
Organismhuman
PubChem CID9962735
SMILES IDCC1=C(C(=C(C(=C1O)OC)OC)O)CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM533554, GSM533555, GSM533556
Perturbed SamplesGSM533557, GSM533558, GSM533559
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE21351
Gene Expression Omnibus
Ubiquinol-induced gene expression signatures are translated into reduced erythropoiesis and LDL cholesterol levels in humans
7
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