Small molecules which reverse Vitamin e treatment
Canned Analysis
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General Information
AccessionDCA00013179
TitleSmall molecules which reverse Vitamin e treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Vitamin e treatment in the Hearts of 30-month-old B6C3F1 animals fed a diet supplemented with alpha-tocopherol cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e1d1e467bea600fb947a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3478
Cell TypeHearts of 30-month-old B6C3F1 animals fed a diet supplemented with alpha-tocopherol
Drug NameVitamin e
DrugBank IDDB00163
Organismmouse
PubChem CID14985
SMILES IDCC1=C(C(=C2CCC(OC2=C1C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)O
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM201741, GSM201753, GSM201767, GSM201768, GSM201770
Perturbed SamplesGSM201772, GSM201773, GSM201775, GSM201777, GSM201778
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE8146
Gene Expression Omnibus
Vitamin E supplementation effect on aged heart
7
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