Small molecules which mimic Lipopolysaccharide treatment
Canned Analysis
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General Information
AccessionDCA00013378
TitleSmall molecules which mimic Lipopolysaccharide treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Lipopolysaccharide treatment in the Neonatal mononuclear cells (from cord blood incubated) - 5 ug/ml LPS cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e467e467bea600fb959c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3595
Cell TypeNeonatal mononuclear cells (from cord blood incubated) - 5 ug/ml LPS
Drug NameLipopolysaccharide
Organismhuman
PubChem CID11970143
SMILES IDCCCCCCCCCCCCCCCC1C(OC(C(C1OC(=O)CC(CCCCCCCCCCC)O)O)COC2C(C(C(C(O2)COC3(CC(C(C(O3)C(CO)O)OC4C(C(C(C(O4)C(CO)O)OP(=O)(O)OP(=O)(O)OCCN)OC5C(C(C(C(O5)C(COC6C(C(C(CO6)(C(CO)O)O)O)O)O)OP(=O)(O)O)OC7C(C(C(C(O7)COC8C(C(C(C(O8)CO)O)O)O)O)OC9C(C(C(C(O9)CO)O)O)OC1C(
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM71081, GSM71082, GSM71083
Perturbed SamplesGSM71084, GSM71085, GSM71086
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE3140
Gene Expression Omnibus
Neonatal mononuclear cell response to lipopolysaccharide
14
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