Small molecules which reverse 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00013391
TitleSmall molecules which reverse 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment in the 17.5 day fetal hearts - 3ug/kg cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e406e467bea600fb9572
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3601
Cell Type17.5 day fetal hearts - 3ug/kg
Drug Name2,3,7,8-tetrachlorodibenzo-p-dioxin
Organismmouse
PubChem CID10852289
SMILES IDCC(C)C=CC(=O)ONC(=O)COC1=CC=C(C=C1)[N+](=O)[O-]
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM60894, GSM60895, GSM60896, GSM60897, GSM60902, GSM60903, GSM60906, GSM60907
Perturbed SamplesGSM60899, GSM60900, GSM60905, GSM60909
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2812
Gene Expression Omnibus
2,3,7,8-tetrachlorodibenzo-p-dioxin effect on cardiovascular development
21
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.