Small molecules which reverse Simvastatin treatment
Canned Analysis
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General Information
AccessionDCA00013423
TitleSmall molecules which reverse Simvastatin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Simvastatin treatment in the Lung (from C57BL/6J) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1db0fe467bea600fb917e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3618
Cell TypeLung (from C57BL/6J)
Drug NameSimvastatin
Organismmouse
PubChem CID54454
SMILES IDCCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM29706, GSM29707, GSM29708
Perturbed SamplesGSM29712, GSM29713, GSM29714
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1871
Gene Expression Omnibus
Inflammatory lung injury and effect of simvastatin
14
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