Small molecules which reverse Fluorouracil treatment
Canned Analysis
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General Information
AccessionDCA00013455
TitleSmall molecules which reverse Fluorouracil treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Fluorouracil treatment in the Bone marrow Sca+ SP hematopoeitic stem cells (HSC) - 2 Day cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1db8de467bea600fb91b6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3636
Cell TypeBone marrow Sca+ SP hematopoeitic stem cells (HSC) - 2 Day
Drug NameFluorouracil
DrugBank IDDB00544
Organismmouse
PubChem CID3385
SMILES IDC1=C(C(=O)NC(=O)N1)F
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM26734, GSM26735
Perturbed SamplesGSM26738, GSM26739
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1559
Gene Expression Omnibus
Hematopoietic stem cell proliferation after 5-fluorouracil treatment: time course
42
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