Small molecules which reverse Orotic acid treatment
Canned Analysis
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General Information
AccessionDCA00013465
TitleSmall molecules which reverse Orotic acid treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Orotic acid treatment in the Livers ( from outbred Wistars - fed a diet with 1% orotic acid) - 1 Day cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e11ee467bea600fb942a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3641
Cell TypeLivers ( from outbred Wistars - fed a diet with 1% orotic acid) - 1 Day
Drug NameOrotic acid
Organismrat
PubChem CID967
SMILES IDC1=C(NC(=O)NC1=O)C(=O)O
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM10009, GSM10010, GSM13064
Perturbed SamplesGSM10003, GSM10004
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE665
Gene Expression Omnibus
Fatty liver disease induced by orotic acid: time course
49
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