Enrichment analysis of genes dysregulated following Vemurafenib treatment
Canned Analysis
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General Information
AccessionDCA00013612
TitleEnrichment analysis of genes dysregulated following Vemurafenib treatment
DescriptionAn enrichment analysis was performed on the top most dyresgulated genes determined by applying the principal angle method to compare gene expression between Vemurafenib treated cells and untreated control cells in the Primary leukemic cells (purified from peripheral blood) - 48 Hours cell type.
Analysis URLhttp://amp.pharm.mssm.edu/PAEA?id=3088008
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2508
Cell TypePrimary leukemic cells (purified from peripheral blood) - 48 Hours
Drug NameVemurafenib
DrugBank IDDB08881
Organismhuman
SMILES IDCCCS(=O)(=O)Nc1ccc(c(c1F)C(=O)c1c[nH]c2c1cc(cn2)c1ccc(cc1)Cl)F
Characteristic Direction parameters
Control SamplesGSM1557452, GSM1557458, GSM1557460, GSM1557464, GSM1557468, GSM1557472
Perturbed SamplesGSM1557453, GSM1557454, GSM1557459, GSM1557461, GSM1557465, GSM1557469, GSM1557473
Tools used in the analysis
Dataset Accession
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE63790
Gene Expression Omnibus
Braf inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia, and exert anti-leukemic activity
14
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