Enrichment analysis of genes dysregulated following Methotrexate treatment
Canned Analysis
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General Information
AccessionDCA00013640
TitleEnrichment analysis of genes dysregulated following Methotrexate treatment
DescriptionAn enrichment analysis was performed on the top most dyresgulated genes determined by applying the principal angle method to compare gene expression between Methotrexate treated cells and untreated control cells in the PBMC cell type.
Analysis URLhttp://amp.pharm.mssm.edu/PAEA?id=3087358
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatoralanstern
CREEDS IDdrug:2541
Cell TypePBMC
Drug NameMethotrexate
DrugBank IDDB00563
Organismhuman
PubChem CID126941
SMILES IDCN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Characteristic Direction parameters
Control SamplesGSM580950, GSM580952, GSM580954, GSM580956, GSM580958, GSM580960, GSM580962, GSM580964, GSM580966, GSM580968, GSM580970
Perturbed SamplesGSM580951, GSM580953, GSM580955, GSM580957, GSM580959, GSM580961, GSM580963, GSM580965, GSM580967, GSM580969, GSM580971
Tools used in the analysis
Dataset Accession
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE23687
Gene Expression Omnibus
Methotrexate effect on SPARKS CHARMS juvenile idiopathic arthritis cohort: peripheral blood mononuclear cells
7
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