Enrichment analysis of genes dysregulated following Methotrexate treatment
Canned Analysis
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General Information
AccessionDCA00013696
TitleEnrichment analysis of genes dysregulated following Methotrexate treatment
DescriptionAn enrichment analysis was performed on the top most dyresgulated genes determined by applying the principal angle method to compare gene expression between Methotrexate treated cells and untreated control cells in the PBMC (peripheral blood mononuclear cells) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/PAEA?id=3088109
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:2601
Cell TypePBMC (peripheral blood mononuclear cells)
Drug NameMethotrexate
DrugBank IDDB00563
Organismhuman
PubChem CID126941
SMILES IDCN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Characteristic Direction parameters
Control SamplesGSM1025164, GSM1025165, GSM1025166, GSM1025167, GSM1025168, GSM1025169, GSM1025170, GSM1025171, GSM1025172, GSM1025173, GSM1025174, GSM1025175, GSM1025176, GSM1025177, GSM1025178
Perturbed SamplesGSM1025179, GSM1025180, GSM1025181, GSM1025182, GSM1025183, GSM1025184, GSM1025185, GSM1025186, GSM1025187, GSM1025188, GSM1025189, GSM1025190, GSM1025191, GSM1025192
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Datasets used in the analysis
Keyword
Tool Name
GSE41831
Gene Expression Omnibus
Remission in Juvenile Idiopathic Arthritis Achieved on Different Drug Regimens
14
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