Enrichment analysis of genes dysregulated following Epz004777 treatment
Canned Analysis
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General Information
AccessionDCA00013739
TitleEnrichment analysis of genes dysregulated following Epz004777 treatment
DescriptionAn enrichment analysis was performed on the top most dyresgulated genes determined by applying the principal angle method to compare gene expression between Epz004777 treated cells and untreated control cells in the MV4 -11 leukemia cell line - Day 6 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/PAEA?id=3088115
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2650
Cell TypeMV4 -11 leukemia cell line - Day 6
Drug NameEpz004777
Organismhuman
PubChem CID56962336
SMILES IDCC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2C(C(C(O2)N3C=CC4=C3N=CN=C4N)O)O
Characteristic Direction parameters
Control SamplesGSM739163, GSM739164, GSM739165
Perturbed SamplesGSM739160, GSM739161, GSM739162
Tools used in the analysis
Dataset Accession
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE29828
Gene Expression Omnibus
Small-molecule DOT1L inhibitor EPZ004777 effect on mixed lineage leukemia cells: time course
26
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