Enrichment analysis of genes dysregulated following Doxycycline treatment
Canned Analysis
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General Information
AccessionDCA00013895
TitleEnrichment analysis of genes dysregulated following Doxycycline treatment
DescriptionAn enrichment analysis was performed on the top most dyresgulated genes determined by applying the principal angle method to compare gene expression between Doxycycline treated cells and untreated control cells in the RT112 cancer cell line (FGFR3 knocked down with shRNA 4-1) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/PAEA?id=3089225
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3040
Cell TypeRT112 cancer cell line (FGFR3 knocked down with shRNA 4-1)
Drug NameDoxycycline
DrugBank IDDB00254
Organismhuman
PubChem CID5281011
SMILES IDCC1C2C(C3C(C(=O)C(=C(N)O)C(=O)C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)N(C)C)O
Characteristic Direction parameters
Control SamplesGSM1007032, GSM1007033, GSM1007046
Perturbed SamplesGSM1007038, GSM1007039, GSM1007052
Tools used in the analysis
Dataset Accession
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE41035
Gene Expression Omnibus
Fibroblast growth factor receptor 3 depletion effect on bladder cancer cell line RT112
85
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