Enrichment analysis of genes dysregulated following 4-hydroxytamoxifen treatment
Canned Analysis
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General Information
AccessionDCA00014053
TitleEnrichment analysis of genes dysregulated following 4-hydroxytamoxifen treatment
DescriptionAn enrichment analysis was performed on the top most dyresgulated genes determined by applying the principal angle method to compare gene expression between 4-hydroxytamoxifen treated cells and untreated control cells in the MCF7 breast cancer cells - 500nM cell type.
Analysis URLhttp://amp.pharm.mssm.edu/PAEA?id=3088860
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3240
Cell TypeMCF7 breast cancer cells - 500nM
Drug Name4-hydroxytamoxifen
Organismhuman
PubChem CID449459
SMILES IDCCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
Characteristic Direction parameters
Control SamplesGSM645710, GSM645711, GSM645718, GSM645719
Perturbed SamplesGSM645714, GSM645715
Tools used in the analysis
Dataset Accession
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE26298
Gene Expression Omnibus
Effect of estrogen receptor- or retinoic acid receptor-knockdown on estrogen-sensitive MCF7 breast cancer cells
21
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