Small molecules which reverse NRAS DEPLETION - siRNA siMut10
Canned Analysis
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General Information
AccessionDCA00019734
TitleSmall molecules which reverse NRAS DEPLETION - siRNA siMut10
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by NRAS DEPLETION - siRNA siMut10 in the 224 melanoma cell line - 1 Day cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21fa4e467bea600fbaf32
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1021
Cell Type224 melanoma cell line - 1 Day
Gene Symbol (human)NRAS
Gene Symbol (mouse)Nras
Organismhuman
Perturbation TypeDEPLETION - siRNA siMut10
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM312684, GSM312685, GSM312686
Perturbed SamplesGSM312687, GSM312688, GSM312689
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE12445
Gene Expression Omnibus
Oncogenic NRAS depletion effect on melanoma cell lines: time course
77
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