Small molecules which reverse PRKAG3 Mutation - R225Q transgenic mutants
Canned Analysis
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General Information
AccessionDCA00019766
TitleSmall molecules which reverse PRKAG3 Mutation - R225Q transgenic mutants
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PRKAG3 Mutation - R225Q transgenic mutants in the Skeletal muscle (gastrocnemius) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2090ce467bea600fba576
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1034
Cell TypeSkeletal muscle (gastrocnemius)
Gene Symbol (human)PRKAG3
Gene Symbol (mouse)Prkag3
Organismmouse
Perturbation TypeMutation - R225Q transgenic mutants
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM93235, GSM93236, GSM93237, GSM93238, GSM93239, GSM93240
Perturbed SamplesGSM93229, GSM93230, GSM93231, GSM93232, GSM93233, GSM93234
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE4065
Gene Expression Omnibus
AMP-activated protein kinase gamma-3 R225Q mutation effect on skeletal muscle
7
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