Small molecules which mimic MBD2 KO
Canned Analysis
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General Information
AccessionDCA00019783
TitleSmall molecules which mimic MBD2 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by MBD2 KO in the CD4+CD25+ Treg cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23701e467bea600fbb97e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1051
Cell TypeCD4+CD25+ Treg
Gene Symbol (human)MBD2
Gene Symbol (mouse)Mbd2
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1182935, GSM1182936, GSM1182937
Perturbed SamplesGSM1182938, GSM1182939, GSM1182940
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE48653
Gene Expression Omnibus
Mbd2 promotes Foxp3 demethylation and T-regulatory cell function
7
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