Small molecules which reverse FOXP3 FOXP3 2T>C(mut)
Canned Analysis
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General Information
AccessionDCA00019794
TitleSmall molecules which reverse FOXP3 FOXP3 2T>C(mut)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by FOXP3 FOXP3 2T>C(mut) in the CD4+ T effector cells, 72h after antiCD3 and antiCD28 stimulation cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2371fe467bea600fbb98c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1055
Cell TypeCD4+ T effector cells, 72h after antiCD3 and antiCD28 stimulation
Gene Symbol (human)FOXP3
Gene Symbol (mouse)Foxp3
Organismhuman
Perturbation TypeFOXP3 2T>C(mut)
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1008440, GSM1008442
Perturbed SamplesGSM1008446, GSM1008448
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE41087
Gene Expression Omnibus
Expression data between FOXP3 wild type and 2T>C(mut)
14
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