Small molecules which reverse XBP1 KO
Canned Analysis
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General Information
AccessionDCA00019796
TitleSmall molecules which reverse XBP1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by XBP1 KO in the CD4+ CD25hi Tregs cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23c8ae467bea600fbbbf0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1060
Cell TypeCD4+ CD25hi Tregs
Gene Symbol (human)XBP1
Gene Symbol (mouse)Xbp1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM990126, GSM990127
Perturbed SamplesGSM990124, GSM990125
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE40273
Gene Expression Omnibus
Gene expression profiling in Treg cells deficient or mutant in candidate FoxP3 cofactors
21
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