Small molecules which mimic CD70 transgene
Canned Analysis
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General Information
AccessionDCA00019849
TitleSmall molecules which mimic CD70 transgene
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by CD70 transgene in the CD71+ bone marrow cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f1dee467bea600fb9b8a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1109
Cell TypeCD71+ bone marrow cells
Gene Symbol (human)CD70
Gene Symbol (mouse)Cd70
Organismmouse
Perturbation Typetransgene
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM562023, GSM562024, GSM562025
Perturbed SamplesGSM562026, GSM562027, GSM562028
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE22656
Gene Expression Omnibus
Expression data from CD71+ cells from the bone marrow of WT, CD70TG, IFNg-/- and CD70TG*IFNg-/- mice.
14
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