Small molecules which mimic TNF KD
Canned Analysis
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General Information
AccessionDCA00019857
TitleSmall molecules which mimic TNF KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by TNF KD in the colon after 5% DSS treatment for induction of IBD mouse model cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d213ace467bea600fbaa24
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1526
Cell Typecolon after 5% DSS treatment for induction of IBD mouse model
Gene Symbol (human)TNF
Gene Symbol (mouse)Tnf
Organismmouse
Perturbation TypeKD
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM790916, GSM790917, GSM790918, GSM790919, GSM790920, GSM790921, GSM790922
Perturbed SamplesGSM790923, GSM790924, GSM790925, GSM790926, GSM790927, GSM790928
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE31906
Gene Expression Omnibus
DSS-induced colitis model response to enhanced siRNA targeting of Tumor necrosis factor
28
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