Small molecules which reverse IDH2 R140Q Allele
Canned Analysis
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General Information
AccessionDCA00019864
TitleSmall molecules which reverse IDH2 R140Q Allele
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by IDH2 R140Q Allele in the Heart tissue cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23b89e467bea600fbbb7e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:1119
Cell TypeHeart tissue
Gene Symbol (human)IDH2
Gene Symbol (mouse)Idh2
Organismmouse
Perturbation TypeR140Q Allele
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1324881, GSM1324882, GSM1324883, GSM1324884
Perturbed SamplesGSM1324885, GSM1324886, GSM1324887, GSM1324888
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE54838
Gene Expression Omnibus
Heart response to isocitrate dehydrogenase 2 mutations IDH2R140Q and IDH2R172K
7
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