Small molecules which reverse IRAK4 IRAK4 kinase deficient mutant
Canned Analysis
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General Information
AccessionDCA00019894
TitleSmall molecules which reverse IRAK4 IRAK4 kinase deficient mutant
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by IRAK4 IRAK4 kinase deficient mutant in the bone-marrow derived macrophages cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f10ae467bea600fb9b30
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1131
Cell Typebone-marrow derived macrophages
Gene Symbol (human)IRAK4
Gene Symbol (mouse)Irak4
Organismmouse
Perturbation TypeIRAK4 kinase deficient mutant
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM229589, GSM229590
Perturbed SamplesGSM229595, GSM229596
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE9037
Gene Expression Omnibus
response to LPS of WT and IRAK4 kinase dead mouse bone marrow macrophages
7
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