Small molecules which reverse ERBB2 OE
Canned Analysis
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General Information
AccessionDCA00019900
TitleSmall molecules which reverse ERBB2 OE
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by ERBB2 OE in the MCF10A cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23062e467bea600fbb696
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormauroccm
CREEDS IDgene:1133
Cell TypeMCF10A
Gene Symbol (human)ERBB2
Gene Symbol (mouse)Erbb2
Organismhuman
Perturbation TypeOE
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1069759, GSM1069760, GSM1069761
Perturbed SamplesGSM1069767, GSM1069768, GSM1069769
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE43730
Gene Expression Omnibus
HER2 and MYC overexpression effect on MCF10A-immortalized breast epithelial cell line
21
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