Small molecules which mimic TRAF6 shRNA
Canned Analysis
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General Information
AccessionDCA00019905
TitleSmall molecules which mimic TRAF6 shRNA
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by TRAF6 shRNA in the TF-1 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f0fee467bea600fb9b2a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1134
Cell TypeTF-1
Gene Symbol (human)TRAF6
Gene Symbol (mouse)Traf6
Organismhuman
Perturbation TypeshRNA
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM944497, GSM944498
Perturbed SamplesGSM944499, GSM944500
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE38519
Gene Expression Omnibus
Cytotoxic effects of Bortezomib in Myelodysplastic syndrome/Acute Myeloid Leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and rep...
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