Small molecules which reverse BRCA1 stable BRCA1 transfection of BRCA1-null cells
Canned Analysis
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General Information
AccessionDCA00019908
TitleSmall molecules which reverse BRCA1 stable BRCA1 transfection of BRCA1-null cells
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by BRCA1 stable BRCA1 transfection of BRCA1-null cells in the HCC1937 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2303ee467bea600fbb686
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1137
Cell TypeHCC1937
Gene Symbol (human)BRCA1
Gene Symbol (mouse)Brca1
Organismhuman
Perturbation Typestable BRCA1 transfection of BRCA1-null cells
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM764323, GSM764324, GSM764325
Perturbed SamplesGSM764320, GSM764321, GSM764322
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE30821
Gene Expression Omnibus
Integration of BRCA1-mediated miRNA and mRNA signatures reveal miR-146a, miR-99b and miR-205 regulation of the TRAF2 and NFkB pathways (mRNA dataset)
7
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