Small molecules which reverse TLR4 KO
Canned Analysis
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General Information
AccessionDCA00019912
TitleSmall molecules which reverse TLR4 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by TLR4 KO in the kidney cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f621e467bea600fb9d64
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1141
Cell Typekidney
Gene Symbol (human)TLR4
Gene Symbol (mouse)Tlr4
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM847664, GSM847665, GSM847666
Perturbed SamplesGSM847670, GSM847671, GSM847672
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE34351
Gene Expression Omnibus
Gene expression profile on ischemic kidneys from wildtype C57BL/10 and TLR4 null C57BL/10ScNJ mice
7
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