Small molecules which reverse RPE65 KD
Canned Analysis
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General Information
AccessionDCA00019914
TitleSmall molecules which reverse RPE65 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by RPE65 KD in the Retina cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22000e467bea600fbaf5a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorshvetank
CREEDS IDgene:1142
Cell TypeRetina
Gene Symbol (human)RPE65
Gene Symbol (mouse)Rpe65
Organismmouse
Perturbation TypeKD
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM70908, GSM70909, GSM70910
Perturbed SamplesGSM70899, GSM70900, GSM70901
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3249
Gene Expression Omnibus
RPE65 null mutant model of Leber's congenital amaurosis
19
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