Small molecules which mimic RPE65 KO
Canned Analysis
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General Information
AccessionDCA00019915
TitleSmall molecules which mimic RPE65 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by RPE65 KO in the epithelial cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23a85e467bea600fbbb08
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormjafari
CREEDS IDgene:2711
Cell Typeepithelial cells
Gene Symbol (human)RPE65
Gene Symbol (mouse)Rpe65
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM70908, GSM70909, GSM70910, GSM70911, GSM70912, GSM70913, GSM70914, GSM70915, GSM70916
Perturbed SamplesGSM70899, GSM70900, GSM70901, GSM70902, GSM70903, GSM70904, GSM70905, GSM70906, GSM70907
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3249
Gene Expression Omnibus
RPE65 null mutant model of Leber's congenital amaurosis
19
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