Small molecules which reverse TLR4 KO
Canned Analysis
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General Information
AccessionDCA00019918
TitleSmall molecules which reverse TLR4 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by TLR4 KO in the lung cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22013e467bea600fbaf62
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1144
Cell Typelung
Gene Symbol (human)TLR4
Gene Symbol (mouse)Tlr4
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM519976, GSM519977, GSM519978
Perturbed SamplesGSM519988, GSM519989, GSM519990
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE20715
Gene Expression Omnibus
Ozone effect on Toll-like receptor 4-deficient C3H/HeJ lung: time course
7
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