Small molecules which reverse IRF7 stable IRF7 transfection (pMSCV)
Canned Analysis
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General Information
AccessionDCA00019920
TitleSmall molecules which reverse IRF7 stable IRF7 transfection (pMSCV)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by IRF7 stable IRF7 transfection (pMSCV) in the 4T1.2 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2204ae467bea600fbaf7a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1146
Cell Type4T1.2
Gene Symbol (human)IRF7
Gene Symbol (mouse)Irf7
Organismhuman
Perturbation Typestable IRF7 transfection (pMSCV)
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM928616, GSM928617, GSM928618
Perturbed SamplesGSM928619, GSM928620, GSM928621
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE37828
Gene Expression Omnibus
Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape mechanisms
7
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