Small molecules which reverse VDR KO
Canned Analysis
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General Information
AccessionDCA00019926
TitleSmall molecules which reverse VDR KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by VDR KO in the Bone marrow derived macrophages (BMDMs) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22738e467bea600fbb286
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:1153
Cell TypeBone marrow derived macrophages (BMDMs)
Gene Symbol (human)VDR
Gene Symbol (mouse)Vdr
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM45581, GSM45586
Perturbed SamplesGSM45580, GSM45587
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE2421
Gene Expression Omnibus
1alpha,25-dihydroxyvitamin D3 suppressive effect on IFN-gamma activated macrophages
21
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