Small molecules which reverse RORA KO
Canned Analysis
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General Information
AccessionDCA00019930
TitleSmall molecules which reverse RORA KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by RORA KO in the liver cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2272fe467bea600fbb282
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1154
Cell Typeliver
Gene Symbol (human)RORA
Gene Symbol (mouse)Rora
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM585667, GSM585668, GSM585669, GSM585670, GSM585671
Perturbed SamplesGSM585672, GSM585673, GSM585674, GSM585675, GSM585676
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE23736
Gene Expression Omnibus
Nuclear receptor, RORa plays a critical role in obesity-associated inflammation, hepatic steatosis, and insulin resistance
14
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