Small molecules which mimic RORA KO
Canned Analysis
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General Information
AccessionDCA00019931
TitleSmall molecules which mimic RORA KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by RORA KO in the white adipose tissue cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22724e467bea600fbb27c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1155
Cell Typewhite adipose tissue
Gene Symbol (human)RORA
Gene Symbol (mouse)Rora
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM585677, GSM585678, GSM585679, GSM585680, GSM585681
Perturbed SamplesGSM585682, GSM585683, GSM585684, GSM585685, GSM585686
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE23736
Gene Expression Omnibus
Nuclear receptor, RORa plays a critical role in obesity-associated inflammation, hepatic steatosis, and insulin resistance
14
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