Small molecules which reverse MYOD1 Mutation - MyoD altered at lysine residues 99, 102, and 104, ren
Canned Analysis
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General Information
AccessionDCA00019990
TitleSmall molecules which reverse MYOD1 Mutation - MyoD altered at lysine residues 99, 102, and 104, ren
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by MYOD1 Mutation - MyoD altered at lysine residues 99, 102, and 104, ren in the Embryonic fibroblasts - 24 Hours cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d220f5e467bea600fbafc6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1180
Cell TypeEmbryonic fibroblasts - 24 Hours
Gene Symbol (human)MYOD1
Gene Symbol (mouse)Myod1
Organismmouse
Perturbation TypeMutation - MyoD altered at lysine residues 99, 102, and 104, ren
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM148422, GSM148426, GSM148427
Perturbed SamplesGSM148429, GSM148434, GSM148445
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE6487
Gene Expression Omnibus
Myogenic transcription factor MyoD mutant expression effect on embryonic fibroblast: time course
14
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