Small molecules which reverse PPARGC1B Hypomorphic Mutation
Canned Analysis
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General Information
AccessionDCA00020010
TitleSmall molecules which reverse PPARGC1B Hypomorphic Mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PPARGC1B Hypomorphic Mutation in the Skeletal muscle - (quadriceps muscles) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d227b6e467bea600fbb2be
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:722
Cell TypeSkeletal muscle - (quadriceps muscles)
Gene Symbol (human)PPARGC1B
Gene Symbol (mouse)Ppargc1b
Organismmouse
Perturbation TypeHypomorphic Mutation
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM143409, GSM143411, GSM143412
Perturbed SamplesGSM143413, GSM143414, GSM143415
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE6210
Gene Expression Omnibus
Transcriptional coactivator PGC-1beta hypomorphic mutation effect on the liver
14
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