Small molecules which mimic ESR1 L540Q point mutation
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00020011
TitleSmall molecules which mimic ESR1 L540Q point mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by ESR1 L540Q point mutation in the MDA-MB-231 human mammary tumor cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d207e4e467bea600fba4f4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorXavier
CREEDS IDgene:1193
Cell TypeMDA-MB-231 human mammary tumor cells
Gene Symbol (human)ESR1
Gene Symbol (mouse)Esr1
Organismhuman
Perturbation TypeL540Q point mutation
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM16943, GSM18491
Perturbed SamplesGSM18496, GSM18497
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1045
Gene Expression Omnibus
Estrogen receptor alpha L540Q mutation effect on gene induction by estradiol: time course
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.