Small molecules which reverse APPL2 KO
Canned Analysis
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General Information
AccessionDCA00020022
TitleSmall molecules which reverse APPL2 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by APPL2 KO in the Prefrontal cortex cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fcf1e467bea600fba020
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorXabi
CREEDS IDgene:852
Cell TypePrefrontal cortex
Gene Symbol (human)APPL2
Gene Symbol (mouse)Appl2
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM636860, GSM636861, GSM636862
Perturbed SamplesGSM636866, GSM636867, GSM636868
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE25926
Gene Expression Omnibus
Amyloid Precursor Protein APP family members: adult prefrontal cortex
35
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