Small molecules which reverse ALDH5A1 KO
Canned Analysis
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General Information
AccessionDCA00020046
TitleSmall molecules which reverse ALDH5A1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by ALDH5A1 KO in the brain hippocampi, cerebella, and cortices cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fd0de467bea600fba02c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormjafari
CREEDS IDgene:2712
Cell Typebrain hippocampi, cerebella, and cortices
Gene Symbol (human)ALDH5A1
Gene Symbol (mouse)Aldh5a1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM53370, GSM53371, GSM53372, GSM53373, GSM53374, GSM53375, GSM53376, GSM53377, GSM53378
Perturbed SamplesGSM53361, GSM53362, GSM53363, GSM53364, GSM53365, GSM53366, GSM53367, GSM53368, GSM53369
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2866
Gene Expression Omnibus
Succinate semialdehyde dehydrogenase deficiency effect on the brain
43
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