Small molecules which mimic TGFB1I1 KD
Canned Analysis
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General Information
AccessionDCA00020051
TitleSmall molecules which mimic TGFB1I1 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by TGFB1I1 KD in the U2OS, osteosarcoma cells, treated with dexamethasone (Dex) for 2h cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f29be467bea600fb9bde
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorchrisliu
CREEDS IDgene:1211
Cell TypeU2OS, osteosarcoma cells, treated with dexamethasone (Dex) for 2h
Gene Symbol (human)TGFB1I1
Gene Symbol (mouse)Tgfb1i1
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1130352, GSM1130380, GSM1130384, GSM1130387
Perturbed SamplesGSM1130340, GSM1130354, GSM1130367, GSM1130386
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE46448
Gene Expression Omnibus
Hydrogen peroxide-inducible clone-5 deficiency effect on dexamethasone-treated osteosarcoma cells: time course
28
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