Small molecules which reverse NF1 Heterozygotic knockout (NF1+/-)
Canned Analysis
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General Information
AccessionDCA00020060
TitleSmall molecules which reverse NF1 Heterozygotic knockout (NF1+/-)
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by NF1 Heterozygotic knockout (NF1+/-) in the hippoccapal tissue postnatal day 10 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f282e467bea600fb9bd4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorXavier
CREEDS IDgene:1218
Cell Typehippoccapal tissue postnatal day 10
Gene Symbol (human)NF1
Gene Symbol (mouse)Nf1
Organismmouse
Perturbation TypeHeterozygotic knockout (NF1+/-)
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM24816, GSM25119, GSM25130
Perturbed SamplesGSM25128, GSM25132, GSM25136, GSM25144
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE1482
Gene Expression Omnibus
Neurofibromatosis and neurodevelopment
60
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