Small molecules which mimic DOT1L INHIBITION - EPZ004777
Canned Analysis
FAIR Metrics
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General Information
AccessionDCA00020113
TitleSmall molecules which mimic DOT1L INHIBITION - EPZ004777
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by DOT1L INHIBITION - EPZ004777 in the MOLM-13 (mixed lineage leukemia (MLL)-rearranged cell line) - 6 Days cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2353ae467bea600fbb8b6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1239
Cell TypeMOLM-13 (mixed lineage leukemia (MLL)-rearranged cell line) - 6 Days
Gene Symbol (human)DOT1L
Gene Symbol (mouse)Dot1l
Organismhuman
Perturbation TypeINHIBITION - EPZ004777
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM739169, GSM739170, GSM739171
Perturbed SamplesGSM739166, GSM739167, GSM739168
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE29828
Gene Expression Omnibus
Small-molecule DOT1L inhibitor EPZ004777 effect on mixed lineage leukemia cells: time course
26
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